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BMS 936558
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DeCS
Descriptor
English
:
Nivolumab
Descriptor
Spanish
:
Nivolumab
Descriptor
Portuguese
:
Nivolumabe
Synonyms
English
:
BMS 936558
BMS-936558
BMS936558
MDX 1106
MDX-1106
MDX1106
ONO 4538
ONO-4538
ONO4538
Opdivo
Tree Number:
D12.776.124.486.485.114.224.060.829
D12.776.124.790.651.114.224.060.829
D12.776.377.715.548.114.224.200.829
Definition
English
:
A genetically engineered, fully humanized immunoglobulin G4 monoclonal antibody that binds to the PD-1 RECEPTOR, activating an immune response to tumor cells. It is used as monotherapy or in combination with
IPILIMUMAB
for the treatment of advanced malignant
MELANOMA
. It is also used in the treatment of advanced or recurring NON-SMALL CELL LUNG CANCER; RENAL CELL
CARCINOMA
; and HODGKIN'S
LYMPHOMA.
Pharmacological Action:
Antineoplastic Agents, Immunological
History Note
English
:
2019 (2010)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
57701
Unique Identifier:
D000077594
Occurrence in VHL
:
Similar:
DeCS